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Bioinformatic > Regulatory Gene

The following information is about Regulatory Gene.

Regulatory Gene Defined

A DNA sequence that functions to control the expression of other genes by producing a protein that modulates the synthesis of their products (typically by binding to the gene promoter). (cf. Structural gene).

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Off-site Regulatory Gene Links, User Submitted

The following links have been collected through user bookmark submission in the Regulatory Gene category. Please note, because these resources are off-site we cannot guarantee the accuracy or quality of any information.

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  • "Loss of putative tumor suppressor EI24/PIG8 confers resistance to etoposide.": "rget gene EI24/PIG8 is lost in invasive breast cancers,sugges ting that EI24/PIG8 is a tumor suppressor that prevents tumor spreading, and partially mediates p53-attributed tumor suppressor activity. EI24/PIG8 also has pro-apoptotic activity indicating that loss of EI24/PIG8 may modulate sensitivity to chemotherapy. Here it is demonstrated that suppression of EI24/PIG8 in fibroblasts and breast cancer cells significantly inhibits the apoptotic response to etoposide treatment. These findings suggest that loss of EI24/PIG8 contributes significantly to resistance of cells to chemotherapeut ic agents that function through p53, and identify the EI24/PIG8 status as a potentially new prognostic marker of chemotherapy responsiveness ."

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Off-site Regulatory Gene Research Links

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