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Heterodimer Defined

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Off-site Heterodimer Links, User Submitted

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Thu Oct 11

• Breast Cancer Research | Full text | Heregulin beta1 drives gefitinib-resi stant growth and invasion in tamoxifen-resi stant MCF-7 breast cancer cells: HRG?1 can overcome the inhibitory effects of gefitinib on cell growth and invasion in Tam-R cells through promotion of erbB3/erbB2 heterodimeriza tion and activation of the phosphatidylin ositol 3-kinase/AKT signalling pathway.

Sun Oct 29

• Entrez PubMed
• Entrez PubMed

Wed Apr 19

• The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation -- Holbro et al. 100 (15): 8933 -- Proceedings of the National Academy of Sciences: These results demonstrate that ErbB2 overexpression and activity alone are insufficient to promote breast tumor cell division. Furthermore, we identify ErbB3's role, which is to couple active ErbB2 to the phosphatidylin ositol 3-kinase/prote in kinase B pa

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Off-site Heterodimer Research Links

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